Blue Boost vs Blue Renew vs Blue Shroom: Which Nutricel Formula Fits Your Day

Pick by what is in the capsule and how you want it to sit in your routine. Blue Boost is the simplest formula: 12 mg of USP grade methylene blue per capsule with vitamin C ester and organic cacao powder, positioned for energy and mental clarity. Blue Renew pairs 7 mg per capsule with hydrolyzed collagen, glycine, NAC and creatine, positioned for healthy aging and brain support. Blue Shroom pairs 7 mg per capsule with six organic mushroom extracts, positioned for cognitive and energy support. Each comes as a 60-capsule bottle.

• Choose Blue Boost if you want the shortest ingredient list and the highest methylene blue amount per capsule of the three.
• Choose Blue Renew if the collagen, GlyNAC (glycine plus NAC) and creatine combination matches what you are looking for.
• Choose Blue Shroom if you want a mushroom-based formula built around busy, full days.

Important: The FDA-approved label for ProvayBlue, a prescription methylene blue injection, carries a boxed warning that methylene blue can cause serious or fatal serotonin syndrome when combined with serotonergic drugs (ProvayBlue label). If you take any prescription medication, talk to your clinician before starting any of these formulas, and review the full adverse medications list.

All three formulas start from the same place: USP grade methylene blue in a 60-capsule bottle, formulated and bottled in the United States at a GMP-compliant facility and independently tested by Eurofins. Nutricel posts the third-party lab reports on its certs page. So the real differences are the methylene blue amount and what sits alongside it.

Amounts are listed per capsule, as shown on each product page. Serving sizes are not the same across the three, so read the serving size on your bottle before you compare cost per day.

Ingredients: USP grade methylene blue (12 mg), vitamin C ester (35 mg) and organic cacao powder (235 mg). That is the whole active list.

Vitamin C ester is the fat-soluble form of vitamin C, which means it can cross cell membranes and reach the same cellular environment as methylene blue. The organic cacao powder is the food-based base of the formula. Nutricel describes methylene blue as helping support mitochondrial function and cellular energy, which is why this formula is positioned for energy and mental clarity.

Who it is for: Nutricel describes the Blue Boost customer as someone with a lot on their plate, such as parents, professionals, entrepreneurs, grandparents and students. It is the natural starting point if you prefer a short ingredient list, and it carries the highest methylene blue amount per capsule of the three, so it is also the one to run past your clinician first if you are unsure about dose. For more detail, read the full Blue Boost breakdown.

Ingredients: USP grade methylene blue (7 mg), hydrolyzed collagen type I and III (258 mg), glycine (86 mg), N-acetyl L-cysteine or NAC (86 mg) and creatine monohydrate (86 mg).

Glycine plus NAC is known as GlyNAC, and it is the center of this formula. GlyNAC has been studied in older adults by researchers at Baylor College of Medicine (Sekhar, J Nutr, 2021; Kumar, J Gerontol A, 2023). Those trials tested GlyNAC supplementation in general, not the Blue Renew capsule. The collagen and creatine are separate additions, each included on its own.

Who it is for: Nutricel describes the Blue Renew customer as an adult who does not want age to define them. It is the most ingredient-dense of the three if you are looking at healthy aging and brain support. For more detail, read the full Blue Renew breakdown.

Ingredients: USP grade methylene blue (7 mg) plus six organic mushroom extracts at 82 mg each: cordyceps, turkey tail, lion's mane, chaga, shiitake and reishi.

Each mushroom brings something different, and none of them depends on another. Lion's mane is the cognitive ingredient of the group, and it is studied for nerve growth factor. In a 2008 lab study, lion's mane extract raised nerve growth factor gene expression in a human astrocytoma cell line and in the hippocampus of mice (Mori et al., 2008). A small 2009 trial in 30 Japanese adults with mild cognitive impairment reported higher cognitive scores with dried lion's mane than with placebo, and the scores fell again after people stopped taking it (Mori et al., 2009). That trial used about 3 g a day, far more than the 82 mg in each Blue Shroom capsule, and it did not test Blue Shroom. Reishi is often called an adaptogen. A 2025 review lists it among natural products with claimed adaptogenic effects and says better clinical research is still needed (Liang et al., 2025). The methylene blue sits underneath as the cellular energy piece.

Who it is for: Nutricel describes the Blue Shroom customer as someone who carries a lot, with busy schedules and full calendars, and who wants to show up well each day. If a mushroom blend appeals to you more than collagen or a short list, this is the one. For more detail, read the full Blue Shroom breakdown.

All three are capsules, so there is nothing to measure or mix. The serving directions on each bottle apply, and your clinician can tell you what amount fits you. If you are weighing capsules against a liquid, see our comparison of methylene blue capsules vs liquid.

Nutricel builds each formula's messaging around a different kind of day. Blue Boost is framed around starting the day with energy and clarity. Blue Renew is framed around keeping up with the things you love. Blue Shroom is framed around staying calm, focused and present through a full schedule. That is how the products are positioned, not a dosing schedule. For questions about timing, read our post on the best time to take methylene blue.

If you are starting out, one formula at a time keeps your routine simple. Whether to combine formulas is a question for your clinician, because the Nutricel catalog does not describe stacking them.

Start with the question that matters most to you.

• You want the simplest label. Blue Boost has three ingredients and the highest methylene blue amount per capsule of the three.
• You are interested in GlyNAC, collagen and creatine. Blue Renew combines them with 7 mg of methylene blue.
• You want a mushroom-based formula. Blue Shroom combines 7 mg of methylene blue with six organic extracts.

If you are still stuck, the ingredient list is the tiebreaker. Read each one on the product page, and compare it with anything else you already take.

Talk to your clinician before starting any of these formulas if any of the following applies to you:

• You take an SSRI, an MAOI or another serotonergic medication. The FDA-approved ProvayBlue prescribing label has a boxed warning that methylene blue can cause serious or fatal serotonin syndrome with serotonergic drugs and says to avoid using it with SSRIs, SNRIs and MAOIs (ProvayBlue label). An in vitro and in silico study found that methylene blue inhibits monoamine oxidase A (Ramsay, Br J Pharmacol, 2007).
• You take any other prescription medication.
• You are pregnant or nursing. Read our post on methylene blue, pregnancy and breastfeeding and talk to your clinician.

Review the full adverse medications list and our guide to methylene blue drug interactions.

You have the facts. The next step is to open the product page that matches your answer, read the full ingredient panel and serving directions, and bring any questions to your clinician.

Questions about a product? Nutricel support answers Monday to Friday, 9 AM to 5 PM EST, with a reply time of about 1 hour.

Safety

• PROVAYBLUE (methylene blue) injection, prescribing information. American Regent. DailyMed, label version June 2025
• Ramsay RR et al. Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Br J Pharmacol, 2007

GlyNAC research

• Sekhar RV. GlyNAC supplementation improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, aging hallmarks, metabolic defects, muscle strength, cognitive decline, and body composition. J Nutr, 2021
• Kumar P et al. Supplementing glycine and N-acetylcysteine (GlyNAC) in older adults: a randomized clinical trial. J Gerontol A Biol Sci Med Sci, 2023

Mushroom research

• Mori K et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull, 2008
• Mori K et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res, 2009
• Liang CJW et al. Safety considerations for natural products with adaptogenic and immunomodulating activities. Pharmaceuticals (Basel), 2025

Nutricel pages

• Nutricel third-party lab reports
• Nutricel adverse medications list

Sam Carlson, Marketing Developer at Nutricel

Sam is a marketing developer at Nutricel, a company based in Melbourne, Florida, who writes the Nutricel Insights series to help customers understand methylene blue and make informed choices. Sam is not a medical professional, and these articles are education rather than medical advice. Talk to your healthcare provider before starting any supplement.