What Is Blue Shroom? Methylene Blue + 6 Mushroom Extracts, Explained

Blue Shroom is our methylene blue capsule with six mushroom extracts added. We built it so each ingredient is studied for something different: methylene blue for how mitochondria pass electrons, lion's mane for nerve growth factor, cordyceps for exercise capacity, and reishi for immune signaling. Below we go through each ingredient, what the research on it actually found, why we chose 7mg of methylene blue, and who the formula is for.

• Blue Shroom delivers 7mg of USP-grade methylene blue per capsule alongside six certified organic mushroom extracts: Lion's Mane, Reishi, Cordyceps, Chaga, Shiitake, and Turkey Tail. Blue Shroom is third-party tested by independent labs and made in a GMP certified facility in the United States.
• The 7mg methylene blue dose is deliberate, not a compromise. Blue Shroom is meant as an everyday stack, so we kept the methylene blue lower than the 12mg in Blue Boost and let the mushrooms carry more of the formula. That is our formulation choice, not something a study compared.
• Blue Shroom is built for sustained cognitive support alongside neuroplasticity and immune resilience, not just acute mental clarity. In the lion's mane study we cite (Mori and colleagues, 2009), the differences showed up after weeks of daily use, not after one dose. That is why we think of Blue Shroom as something you take every day, not a pick-me-up.

Important: The FDA label for methylene blue injection (Provayblue) warns about serotonin syndrome with serotonergic medications, including SSRIs and MAOIs. Review the full adverse medications list before starting any methylene blue protocol.

Blue Shroom is for people who want one daily capsule for focus, energy, and immune support, instead of three bottles. Most mushroom blends lean on the same group of compounds, beta-glucans, across every mushroom in them. We wanted ingredients that are each studied for something different.

Blue Shroom pairs 7mg of USP-grade methylene blue with six organic mushroom extracts: Lion's Mane, Reishi, Cordyceps, Chaga, Shiitake, and Turkey Tail. Methylene blue is studied for its role in the mitochondrial electron transport chain, the line your cells use to make energy. Lion's Mane is studied for nerve growth factor. Cordyceps has been studied for exercise capacity. Reishi is studied for immune signaling. Chaga, Shiitake, and Turkey Tail round it out with their own beta-glucans and antioxidant compounds.

We picked them so that no two are there for the same reason. To be clear about the limit: each ingredient has been studied on its own, and nobody has run a study on this exact combination. Blue Shroom is a stack we designed, not a formula a trial tested.

We use 7mg because more is not better with methylene blue. Gonzalez-Lima and Auchter (Frontiers in Cellular Neuroscience, 2015) describe it as hormetic: in the studies they review, low doses supported mitochondrial function and high doses had the opposite effect. Even the "low doses" in that research, done mostly in cells and animals, are several times more than one 7mg capsule.

Blue Shroom uses 7mg per capsule, a little over half of Blue Boost. That was a formulation call, not a cost one. Blue Boost is the formula for people who mainly want methylene blue. In Blue Shroom, methylene blue is one part of a wider stack, so we gave it a smaller share. No study has tested 7mg against 12mg in this blend, so read that as our reasoning, not a finding.

Your cells make energy by passing electrons down a chain, a bit like a bucket line. Rojas and colleagues (Progress in Neurobiology, 2012) describe methylene blue accepting electrons from NADH and handing them to cytochrome c, a route around two steps of that chain (Complexes I and III). In their review, that is how methylene blue is thought to support ATP production and lower oxidative stress. Most of that work comes from cells and animals, so it explains why researchers are interested, not what a capsule will do for you.

The methylene blue in Blue Shroom is USP grade, meaning it meets the United States Pharmacopeia standard, and our raw material tested at 99.4% purity. That matters because industrial-grade methylene blue, sold for dyes and aquariums, can be much less pure and can carry heavy metals such as arsenic, lead, and cadmium. The Blue Shroom third-party lab report is published on the Nutricel certifications page.

Lion's Mane (Hericium erinaceus) is the main focus ingredient in Blue Shroom, and it is studied for something different from methylene blue. Methylene blue is studied for energy production inside cells. Lion's Mane is studied for nerve growth factor (NGF), a protein neurons need to stay healthy and grow. We paired them on purpose.

Kawagishi's group, who first isolated them, report that hericenones from the fruiting body and erinacines from the mycelium stimulated NGF production in lab and animal studies (Wang and colleagues, Journal of Natural Products, 2025). In people, the best-known trial is Mori and colleagues (Phytotherapy Research, 2009): 30 Japanese adults aged 50 to 80 with mild cognitive impairment. The lion's mane group scored higher on a cognitive scale than placebo at weeks 8, 12, and 16, and the scores dropped again four weeks after they stopped. Keep the size in mind: 15 people per group, taking 3 grams of dried mushroom a day.

The practical point: in that trial, the difference took weeks to show up. The first difference from placebo was measured at week 8. If you try Blue Shroom for two weeks and feel nothing, that does not tell you much about the lion's mane part of it.

Why Lion's Mane and Methylene Blue Together?

Our reasoning is simple. Building and maintaining connections between neurons takes energy, and methylene blue is studied for its role in how cells make that energy (Rojas and colleagues, 2012). Lion's Mane is studied for the growth signal itself. That is a rationale for putting them together, not a result anyone has measured, and we would rather say so plainly.

Reishi (Ganoderma lucidum) is in Blue Shroom for immune and stress support. It is one of the most studied mushrooms there is, and a 2020 review by Ahmad (Journal of Ethnopharmacology) names polysaccharides and triterpenoids as its main active compounds.

The same review describes reishi's polysaccharides as immune modulators, compounds that adjust immune signaling rather than simply turning it up. That is the reason reishi is usually called an adaptogen rather than an immune stimulant. The triterpenoids, such as ganoderic acids, are studied separately for the body's inflammatory response. Most of this research is in cells and animals.

Reishi has a long history of use for stress and calm, which is a big part of why we included it. We have not found strong human trials on reishi and stress, so we are not going to promise a result.

If reishi does anything for you, expect it to be quiet. It is not the kind of ingredient you feel an hour after taking it.

Cordyceps (Cordyceps militaris) is the energy and endurance ingredient in Blue Shroom. Methylene blue is studied for the electron transport chain inside mitochondria. Cordyceps is studied for something else: how well the body uses oxygen during exercise.

The best-known compound in Cordyceps militaris is cordycepin (3'-deoxyadenosine), which is shaped much like adenosine, a building block of ATP. Most of the research on how cordycepin works is from the lab, so we lean on the human exercise studies below instead.

Chen and colleagues (Journal of Alternative and Complementary Medicine, 2010) gave 20 healthy adults aged 50 to 75 a cordyceps extract (Cs-4) or placebo for 12 weeks. In the cordyceps group, metabolic threshold rose 10.5% and ventilatory threshold rose 8.5%, with no change in the placebo group and no change in VO2 max in either. A smaller study by Colson and colleagues (Journal of Strength and Conditioning Research, 2005) gave 8 male cyclists a cordyceps and rhodiola formula and found no significant difference in muscle oxygen saturation or performance. So the human evidence is two small studies, one encouraging and one flat.

We included cordyceps for people who stay active, the walkers, gardeners, and weekend cyclists, because the exercise studies are where it has been tested. We do not claim it changes how you feel at a desk at 3 pm.

Chaga, Shiitake, and Turkey Tail are in Blue Shroom for general antioxidant and immune support. They have a longer history of traditional use than of human trials, so this section is shorter on claims than the ones above.

Chaga

Chaga (Inonotus obliquus) grows on birch trees and has long been brewed as a tea. It contains melanin pigments and betulinic acid, which are studied in the lab for antioxidant activity. We include chaga as an antioxidant source alongside the other ingredients, and we are not aware of good human trials on chaga on its own.

Shiitake

Shiitake (Lentinula edodes) is a common food mushroom. Its best-known compound is lentinan, a beta-glucan that has been studied for immune cell activity. As a food, shiitake also brings small amounts of minerals and B vitamins.

Turkey Tail

Turkey Tail (Trametes versicolor) is best known for two compounds, PSK and PSP, which have a long research history as immune-active polysaccharides. Its fibers are also studied as a prebiotic, food for the bacteria in your gut. We include it for immune and gut support, as one part of the blend rather than the reason to buy it.

We suggest the same easy start we suggest for all our methylene blue products, and it matters more here if mushroom extracts are new to you too. Go slowly in the first week so you can tell how your stomach and your sleep handle it. Check with your doctor first, especially if you take any medication.

Morning Dosing Only

Take Blue Shroom in the morning. Some people find methylene blue a little energizing, and the FDA label for methylene blue injection (Provayblue) gives its half-life as about 24 hours, so it stays in your system for a while. We suggest morning with a light meal for every one of our methylene blue products.

One Capsule Per Day Is the Correct Maximum

One capsule a day is the label direction, and we do not suggest taking two. Two would double both the methylene blue (to 14mg) and the mushroom extracts, and with a hormetic compound, more is not the goal. A bottle of 60 lasts two months at one a day, which is about the length of the lion's mane trial.

Read this before anything else on the page. Blue Shroom contains methylene blue, and the FDA label for methylene blue injection (Provayblue) carries a boxed warning about serotonin syndrome when it is combined with serotonergic drugs. Our adverse medications list goes further.

Do not take Blue Shroom if you are currently using:

• SSRIs, SNRIs, or MAOIs (the FDA label warns of serotonin syndrome, which can be fatal)
• Tramadol, linezolid, bupropion, trazodone, or other serotonergic medications
• Supplements including St. John's Wort, 5-HTP, or SAMe
• Blood pressure medications

Do not take Blue Shroom if you have: G6PD deficiency (the Provayblue label warns of hemolytic anemia), methemoglobin reductase deficiency, or known hypersensitivity to methylene blue or any mushroom species in the formula. Not for use by pregnant or nursing women.

Review the full adverse medications list and consult your healthcare provider before starting Blue Shroom or any methylene blue product.

Every Nutricel product uses USP-grade methylene blue, is made in an GMP certified facility in the United States, and our capsules are third-party tested by independent labs. The difference between them is what goes in alongside the methylene blue.

Blue Shroom - 7mg MB + Lion's Mane, Reishi, Cordyceps, Chaga, Shiitake, Turkey Tail. For people who want focus, immune, and energy support in one daily capsule and plan to take it for the long run.

Blue Boost is our core formula: 12mg of methylene blue per capsule with Vitamin C Ester and organic cacao. If you mainly want methylene blue itself, start here.

Blue Immune combines methylene blue with copper, magnesium, NAC, grass-fed beef liver, and camu camu for fatigue and cellular energy support, based on the Root Cause Protocol.

Blue Renew is built around GlyNAC with collagen and creatine, aimed at longevity and brain function as you age.

Blue Remove combines zeolite, curcumin, and nattokinase, aimed at circulation and the body's normal inflammatory response.

Blue Liquid is USP-grade methylene blue in a dropper bottle (1%, 10mg per mL), for people who prefer liquid and want to adjust in small steps.

Blue Shroom is methylene blue plus six mushrooms, each picked for a different reason: methylene blue for cellular energy, Lion's Mane for nerve growth factor, Reishi for immune signaling, Cordyceps for exercise capacity, Chaga for antioxidants, Shiitake for beta-glucans, and Turkey Tail for gut support.

We chose 7mg of methylene blue so it is one part of the stack rather than the whole thing. Each ingredient has research behind it on its own. The combination itself has not been studied, and we would rather tell you that than imply otherwise.

Give it longer than you would give Blue Boost. In the lion's mane and cordyceps studies we cite, results were measured after 8 to 16 weeks of daily use, so two months is a fair trial.

Blue Shroom contains 7mg USP-grade methylene blue per capsule alongside six certified organic mushroom extracts, and it is third-party tested by independent labs. The lab report is published on the Nutricel certifications page. Before starting, review the full adverse medications list and confirm with your healthcare provider that no contraindications apply to your situation.

Methylene Blue and Mitochondrial Mechanisms

Lion's Mane and Nerve Growth Factor

Cordyceps, Reishi, and Supporting Mushrooms

Nutricel Product and Safety Information

Sam Carlson, Marketing Developer at Nutricel

Sam is a marketing developer at Nutricel who writes the Nutricel Insights series to help our customers understand methylene blue and make informed choices, translating the published research into plain language. Sam is not a medical professional, and these articles are intended as education rather than medical advice. Every figure in this piece is tied to the studies listed in the references, and you should always speak with your healthcare provider before starting any supplement.